RAPID COMMUNICATION Mutations in the Wilms’ Tumor Gene WT1 in Leukemias

نویسندگان

  • L. King - Underwood
  • J. Renshaw
  • K. Pritchard - Jones
چکیده

The tissue-specific Wilms‘ tumor gene W1 is expressed in a range of acute leukemias and hematopoietic cell lines. Using single-strand conformational polymorphism analysis, we have found mutations in the W1 gene in 4 of 36 acute leukemias. W1 mutations are found in 15% of cases of acute myeloid leukemia, in which they are associated with a poor response to chemotherapy. The mutations comprise small

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Mutations in the Wilms' tumor gene WT1 in leukemias.

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تاریخ انتشار 2002